Chloroquine-chemotherapy combination holds potential for metastatic breast cancer treatment
December 30, 2019
"We're very hopeful that this is a new paradigm that we can apply, repurposing old drugs for 5 cents a day that may make an impact in reversing treatment-resistance in women with breast cancer," said Chang, a breast medical oncologist.
Physicians began using chloroquine in the late 1940s for the prevention and treatment of malaria, after United States government-sponsored clinical trials showed that the drug had a significant impact as an anti-malarial drug. Chloroquine mildly suppresses the immune system, and it is used in some autoimmune disorders, such as rheumatoid arthritis and lupus. Chloroquine is also being studied as a treatment in patients with relapsed multiple myeloma, pancreatic cancer, glioblastoma multiforme, and small cell lung cancer.
Previous research stemming from a chloroquine vaccination program in Tanzania showed the incidence of Burkitts lymphoma fell by 75 percent. Two years after the study ended the incidence of Burkitt's lymphoma returned to baseline. Chang said these research results are an indication that chloroquine may also be used for prevention as well as treatment.
Source Methodist Cancer Center